Publications

Selected Publications

Research Papers

• • • Sucrose overconsumption impairs AgRP neuron dynamics and promotes palatable food intake.

      Lorch CM, Hayes NW, Xia JL, Fleps SW, McMorrow HE, Province HS, Frydman JA, Parker JG, Beutler LR

      Cell Rep. 2024 Jan; 43(2): 113675.

      https://doi.org/10.1016/j.celrep.2024.113675

      PMID: 38224492

• • • Obesity causes selective and long-lasting desensitization of AgRP neurons to dietary fat.

      Beutler LR, Corpuz TV, Ahn JS, Kosar S, Song W, Chen Y, Knight ZA

      Elife. 2020 Jul; 9:e55909

      https://doi.org/10.7554/eLife.55909

      PMID: 32720646

• • • Genetic Identification of Vagal Sensory Neurons That Control Feeding.

      Bai L, Mesgarzadeh S, Ramesh KS, Huey EL, Liu Y, Gray LA, Aitken TJ, Chen Y, Beutler LR, Ahn JS, Madisen L, Zeng H, Krasnow MA, Knight ZA

      Cell. 2019 Nov; 179(5): 1129-1143.e23.

      https://doi.org/10.1016/j.cell.2019.10.031

      PMID: 31730854

• • • A gut-to-brain signal of fluid osmolarity controls thirst satiation.

      Zimmerman CA, Huey EL, Ahn JS, Beutler LR, Tan CL, Kosar S, Bai L, Chen Y, Corpuz TV, Madisen L, Zeng H, Knight ZA

      Nature. 2019 Apr; 568(7750): 98-102.

      https://doi.org/10.1038/s41586-019-1066-x

      PMID: 30918408

• • • Dynamics of Gut-Brain Communication Underlying Hunger.

      Beutler LR, Chen Y, Ahn JS, Lin Y-C, Essner RA, Knight ZA

      Neuron. 2017 Oct; 96(2): 461-475.e5.

      https://doi.org/10.1016/j.neuron.2017.09.043

      PMID: 29024666

• • • The contribution of NMDA receptor signaling in the corticobasal ganglia reward network to appetitive Pavlovian learning.

      Parker JG, Beutler LR, Palmiter RD

      J Neurosci. 2011 Aug; 31(31): 11362-11369.

      https://doi.org/10.1523/JNEUROSCI.2411-11.2011

      PMID: 21813695

• • • Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization.

      Beutler LR, Wanat MJ, Quintana A, Sanz E, Bamford NS, Zweifel LS, Palmiter RD

      Proc Natl Acad Sci U S A. 2011 Mar; 108(10): 4206-4211.

      https://doi.org/10.1073/pnas.1101424108

      PMID: 21368124

• • • Severely impaired learning and altered neuronal morphology in mice lacking NMDA receptors in medium spiny neurons.

      Beutler LR, Eldred KC, Quintana A, Keene CD, Rose SE, Postupna N, Montine TJ, Palmiter RD

      PLoS One. 2011; 6(11): e28168.

      https://doi.org/10.1371/journal.pone.0028168

      PMID: 22132236